Mitsu Ikura

From

Mitsu Ikura
Ontario Cancer Institute, Room 7-707
416-946-2025

My laboratory is interested in elucidating structure-function relationships of biological macromolecules. Of particular interest are proteins involved in calcium signalling, cell-cell interactions and transcriptional regulation (see research projects). Our primary tool is high-resolution NMR spectroscopy, but we also use a variety of biophysical and molecular biology techniques, including X-ray crystallography and in vivo FRET (fluorescence resonance energy transfer) imaging microscopy. Our laboratory has also conducted structural bioinformatics studies involving the development of sequence/structure/function-integrated databases specifically designed for the EF-hand protein superfamily and for calmodulin binding proteins. Future studies will include structure-function studies of various biologically or clinically important proteins and protein-protein complexes as well as development of other databases on specific protein superfamilies. Combining detailed structural analysis of proteins by NMR and X-ray crystallography with in vivo FRET imaging, structural bioinformatics and genetic and biochemical characterization of proteins' biological functions offers not only a promising future for fundamental molecular biology, but also excellent platforms for drug discovery enterprise targeting various disease-linked gene products.

Ikura lab website http://nmr.uhnres.utoronto.ca/ikura

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