Khosrow Adeli


Khosrow Adeli
Hospital for Sick Children, Room 3653, Atrium

Molecular and cellular biology of lipoprotein metabolism in insulin-resistant states such as obesity and diabetes, and the link with cardiovascular disease The incidence of insulin resistant states such as obesity and type 2 diabetes have been increasing at an alarming rate in recent years in both paediatric and adult populations. Our research program aims to elucidate the key genetic and environmental factors that link insulin resistance, lipoprotein abnormalities, and cardiovascular disease. We are investigating the underlying cellular and molecular mechanisms of the development of metabolic dyslipidaemia in insulin-resistant states. Using diet-induced animal models of insulin resistance and obesity, we are investigating the link between the insulin signalling pathway and deregulation of hepatic and intestinal lipoprotein metabolism. Proteomic and genomic tools are being employed to identify hepatic and intestinal proteins that are differentially expressed in the state of insulin resistance. Morand JP, Macri J, Adeli K. Proteomic profiling of hepatic ER proteins in an animal model of insulin resistance and metabolic dyslipidemia. J. Biol Chem. 2005 May 6;280(18):17626-33

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