Jeff Wrana

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Jeff Wrana
Rm. 1075, Samuel Lunenfeld Research Institute
416-586-4800 ext. 2791

Cell signalling in development and cancer. My lab is interested in how networks controlling morphogenetic responses during early development are misassembled in complex diseases such as cancer . We employ high-throughput approaches to develop physical and functional maps of dynamic networks in mammalian cells and relate these to cell behaviour and cancer progression. In addition we have an active interest in applying cell-based screening methods to develop mammalian genome-wide siRNA and chemical genetic approaches to understanding network topology and function.

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